地学前缘 ›› 2020, Vol. 27 ›› Issue (5): 291-299.DOI: 10.13745/j.esf.sf.2020.5.52

• 宝玉石、矿产综合利用、工艺及生命矿物研究中的成因矿物学 • 上一篇    下一篇

脑动脉粥样硬化斑块中不同类型钙化集合体的矿物学特征及分布规律

李源，王长秋，鲁安怀，李艳，杨重庆，李康   

  1. 1. 北京大学 地球与空间科学学院 造山带与地壳演化教育部重点实验室/矿物环境功能北京市重点实验室, 北京 100871
    2. 北京医院 病理科, 北京 100730
    3. 北京医院 心内科, 北京 100730
  • 收稿日期:2020-03-15 修回日期:2020-05-10 出版日期:2020-09-25 发布日期:2020-09-25
  • 通讯作者: 王长秋(1965—)，男，博士，副教授，主要从事矿物学研究。
  • 作者简介:李源(1990—)，男，博士研究生，主要从事人体病理性矿化方面的研究。E-mail:urey091126@163.com
  • 基金资助:

    国家自然科学基金项目(41772033，41272048，40972210)

Mineralogical characteristics and distribution patterns of different types of calcification in a cerebrovascular atherosclerotic lesion

LI Yuan, WANG Changqiu, LU Anhuai, LI Yan, YANG Chongqing, LI Kang   

  1. 1. MOE Key Laboratory of Orogenic Belts and Crustal Evolution/Beijing Key Laboratory of Mineral Environmental Function, School of Earth and Space Sciences, Peking University, Beijing 100871, China
    2. Department of Pathology, Beijing Hospital, Beijing 100730, China
    3. Department of Cardiology, Beijing Hospital, Beijing 100730, China
  • Received:2020-03-15 Revised:2020-05-10 Online:2020-09-25 Published:2020-09-25

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摘要：

钙化是脑动脉粥样硬化的重要指示，并与粥样硬化的发展密切相关。脑动脉粥样硬化斑块钙化灶中存在球状与块状两类不同形貌的矿物集合体，但是关于两类钙化矿物学特征的区别以及其在病灶中空间分布规律的研究仍不充分。选取具有不同程度钙化的脑动脉粥样硬化样品，利用扫描电子显微镜(SEM)及其附带的能谱仪(EDS)、透射电子显微镜(TEM)及其附带的选区电子衍射(SAED)以及拉曼光谱(Raman)，对钙化物的形貌、构造以及基于空间分布的物相组成及化学成分的变化进行了研究。研究表明，钙化灶中心由块状钙化构成，周围分布着球状钙化。块状钙化中物相分布不均匀，其中心由碳羟磷灰石(CHA)构成，边缘除CHA外还含有部分无定型磷酸钙(ACP)。球状钙化由白磷钙石(WH)与CHA构成。

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关键词: 脑动脉, 动脉粥样硬化, 球状钙化, 碳羟磷灰石, 白磷钙石

Abstract:

Cerebral artery calcification is an important indication of atherosclerotic plaques and closely related to the atherosclerotic process. In the cerebral artery, calcification mostly appears as spherical or massive mineral aggregates, but the difference between these two types and their spatial distribution patterns in an atherosclerotic lesion are still not clear. Therefore, we collected and analyzed samples with different stages of calcification by environmental scanning electron microscope (SEM) with energy disperse spectroscopy (EDS), transmission electron microscope (TEM) with selected area electron diffraction (SAED) and Raman spectroscopy (Raman). We studied the morphology, structure and spatial distribution of phase and chemical composition of calcification in the atherosclerotic plaque. The results showed that the center of the calcified area develops massive calcification and its surrounding develops spherical calcification. The center of massive calcification is composed of carbonate hydroxyapatite (CHA) while the edge also contains small fraction of amorphous calcium phosphate (ACP). Spherical calcification is composed of whitlockite (WH) and CHA.

Key words: cerebral artery, atherosclerotic plaques, spherical calcification, carbonate hydroxyapatite, whitlockite

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